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NSG 5003 Week 2 Case Study 2: Case 2

Student name South University NSG-5003 Professor Name Submission Date Case Study 2: Case 2 Clinical symptoms of a patient with a lymph node that is painless and slowly growing cervical lymph node and fatigue place a patient under clinical suspicion of having a lymphoprolliferative tumor, such as Hodgkin lymphoma (Bhalala et al., 2024). In this case, a systematic assessment should be offered to identify the diagnosis and eliminate the other causes of lymphadenopathy. Additional Clinical Presentation in Line with Hodgkin Lymphoma Although one of the traditional B symptoms (fatigue) is observed in the patient, other systemic effects of the Hodgkin lymphoma phenomenon are the cardinal B symptoms of unusual fever (in most cases cyclical), night sweats (that are drenching), and severe weight loss (more than 10% of body mass in 6 months). Another common characteristic is the absence of a rash and generalized pruritus (itche), (Cardoso & Goncalves, 2024). The disease may be manifested in the mediastinum in case of the progression of the disease, which can be manifested by cough, chest pain, or dyspnea. The swelling of lymph nodes can also take place in other locations (axillary, inguinal) or at the spleen. Other Possible Diagnoses This presentation can be imitated under a number of conditions. The active or recurring infection with EBV (Epstein-Barr Virus) is one of the main aspects to be considered, including his age and the presence of mononucleosis. The others are infectious in nature and are toxoplasmosis, cytomegalovirus (CMV), or HIV. This is also echoed in the non-Hodgkin lymphomas. However, non-malignant causes may also take place and include sarcoidosis, an inflammatory disease that leads to the swelling of the lymph nodes or reactive lymphadenopathy which is a localized subclinical infection (Kuppers, 2024). Diagnostic Tests and Promised Discoveries The final diagnosis is the lymph node excisional biopsy that is evaluated to inform about the histopathological, which would stimulate the Reed-Sternberg cells which is a characteristic of the Hodgkin lymphoma. Before passing on to the biopsy, the initial tests are: CBC (Complete Blood Count): It could contain slight enlargement of the quantity of white cells – WBC (lymphocytosis or eosinophilia). Sometimes thrombocytosis is also observed. Erythrocyte Sedimentation rate (ESR) or C-Reactive Protein (CRP): These are inflammatory biomarkers which are normally elevated in enormous amounts, which is associated with the action of the disease, and which is associated with the presence of B symptoms. Liver Function Tests (LFTs) and Lactate Dehydrogenase (LDH): In most cases, LDH is also elevated and is a cell turnover value. A chest X-ray could be useful in the identification of mediastinal adenopathy. The Chest, abdominal, and pelvis Computed Tomography (CT) is necessary to determine the degree to which the lymph nodes are invaded and the presence or absence of the invaded organs (Kuppers, 2024). Conclusion The fact that a painless, fixed, and rubbery lymph node is attached to issues on a system level requires a pressing and detailed inquiry. One should not make a differential diagnosis despite the fact that Hodgkin lymphoma is a big problem. The diagnostic process chronology starts with the initial blood and radiographic test, after which a confirmatory biopsy is done to proceed with the process of the final diagnostic and treatment plan. Early and appropriate diagnosis is a prognosis of a good prognosis of Hodgkin lymphoma. References Cardoso, T., & Gonçalves, L. (2024). Hodgkin lymphoma is the underlying cause of a chronic cough. Cureus, 11(16), e74778. https://doi.org/10.7759/cureus.74778 Küppers, R. (2024). Advances in Hodgkin lymphoma research. Trends in Molecular Medicine, 31(4), 326–343. https://doi.org/10.1016/j.molmed.2024.10.004

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